NU7026

NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)

NU7026

NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)

From: 100 USD
Catalog #
74172_C
NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)

Overview

NU7026 is an inhibitor of DNA-dependent protein kinase (DNA-PK), an enzyme involved in the non-homologous end joining (NHEJ) DNA repair pathway. NU7026 sensitizes cells to radiation and has potential for anticancer therapies (Veuger et al.). NU7026 is also reported to increase the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Riesenberg & Maricic; Zhang et al.).


GENOME EDITING
· Increases precise genome editing by promoting HDR at the expense of NHEJ in human pluripotent stem cells (Riesenberg & Maricic; Zhang et al.).

CANCER RESEARCH
· Sensitizes human cancer cell lines to DNA double-strand break-inducing therapy (chemo- or radio-therapy) by inhibiting DNA-PK activity and inducing cell cycle arrest at G2/M phase (Albarakati et al.; Ma et al.; Niazi et al.; Willmore et al.; Yang et al.).
Alternative Names
LY293646; DNA-PK Inhibitor II
Cell Type
Cancer Cells and Cell Lines, Leukemia/Lymphoma Cells, Pluripotent Stem Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Genome Editing
Area of Interest
Cancer, Immunology, Stem Cell Biology
CAS Number
154447-35-5
Chemical Formula
C₁₇H₁₅NO₃
Molecular Weight
281.3 g/mol
Purity
≥ 95%

Scientific Resources

Product Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Product Name
NU7026
Catalog #
74172, 74174
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
NU7026
Catalog #
74172, 74174
Lot #
All
Language
English

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Contact STEMCELL Technologies

Our Customer Service, Sales, and Product and Scientific Support departments in North America are available between 6 am and 5 pm Pacific Time (9 am and 8 pm Eastern Time). One of our representatives will be happy to help you by telephone or email. Please complete the form to contact us by email. A representative will get back to you shortly.
  •  

StemCell Technologies Inc. and affiliates ("STEMCELL Technologies") does not share your email address with third parties. StemCell Technologies Inc. will use your email address to confirm your identity and send you newsletters, transaction-related emails, promotional and customer service emails in accordance with our privacy policy. You can change your email preferences at any time.