NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)
· Increases precise genome editing by promoting HDR at the expense of NHEJ in human pluripotent stem cells (Riesenberg & Maricic; Zhang et al.).
· Sensitizes human cancer cell lines to DNA double-strand break-inducing therapy (chemo- or radio-therapy) by inhibiting DNA-PK activity and inducing cell cycle arrest at G2/M phase (Albarakati et al.; Ma et al.; Niazi et al.; Willmore et al.; Yang et al.).
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
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