FK506
Calcineurin/NFAT pathway inhibitor; Binds FKBP-12
Overview
FK506 is a macrolide antibiotic with potent immunosuppressive properties (Thomson et al.). It inhibits the calcineurin/NFAT pathway (Martinez-Martinez & Redondo) and binds with high affinity to FK506 binding protein 12 (FKBP-12) (Thomson et al.).
MAINTENANCE AND SELF-RENEWAL
· Promotes the self-renewal of mouse embryonic stem cells independent of leukemia inhibitory factor (LIF), and attenuates differentiation following LIF withdrawal (Li et al.).
· In combination with 1-Azakenpaullone (Catalog #74252) and ID-8 (Catalog #72502), enhances the expansion rates of several human pluripotent stem cell lines (Yasuda et al.).
IMMUNOLOGY
· Inhibits pro-inflammatory cytokine production by activated T cells (Sakuma et al.).
MAINTENANCE AND SELF-RENEWAL
· Promotes the self-renewal of mouse embryonic stem cells independent of leukemia inhibitory factor (LIF), and attenuates differentiation following LIF withdrawal (Li et al.).
· In combination with 1-Azakenpaullone (Catalog #74252) and ID-8 (Catalog #72502), enhances the expansion rates of several human pluripotent stem cell lines (Yasuda et al.).
IMMUNOLOGY
· Inhibits pro-inflammatory cytokine production by activated T cells (Sakuma et al.).
Alternative Names
Tacrolimus
Cell Type
Mononuclear Cells, T Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Maintenance
Area of Interest
Cell Therapy Research, Immunology
CAS Number
104987-11-3
Chemical Formula
C₄₄H₆₉NO₁₂
Molecular Weight
804.0 g/mol
Purity
≥ 99%
Related Products
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Scientific Resources
Product Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
FK506
Catalog #
74152, 74154 Lot #
All Language
English Document Type
Safety Data Sheet
Product Name
FK506
Catalog #
74152, 74154 Lot #
All Language
English Educational Materials (3)
Product Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for
Human Pluripotent Stem Cell Research
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
