FK506

Calcineurin/NFAT pathway inhibitor; Binds FKBP-12

FK506

Calcineurin/NFAT pathway inhibitor; Binds FKBP-12

From: 168 USD
Catalog #
74152_C
Calcineurin/NFAT pathway inhibitor; Binds FKBP-12

Overview

FK506 is a macrolide antibiotic with potent immunosuppressive properties (Thomson et al.). It inhibits the calcineurin/NFAT pathway (Martinez-Martinez & Redondo) and binds with high affinity to FK506 binding protein 12 (FKBP-12) (Thomson et al.).


MAINTENANCE AND SELF-RENEWAL
· Promotes the self-renewal of mouse embryonic stem cells independent of leukemia inhibitory factor (LIF), and attenuates differentiation following LIF withdrawal (Li et al.).

· In combination with 1-Azakenpaullone (Catalog #74252) and ID-8 (Catalog #72502), enhances the expansion rates of several human pluripotent stem cell lines (Yasuda et al.).


IMMUNOLOGY
· Inhibits pro-inflammatory cytokine production by activated T cells (Sakuma et al.).
Alternative Names
Tacrolimus
Cell Type
Mononuclear Cells, T Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Maintenance
Area of Interest
Cell Therapy Research, Immunology
CAS Number
104987-11-3
Chemical Formula
C₄₄H₆₉NO₁₂
Molecular Weight
804.0 g/mol
Purity
≥ 99%

Scientific Resources

Product Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Product Name
FK506
Catalog #
74152, 74154
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
FK506
Catalog #
74152, 74154
Lot #
All
Language
English

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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