1-Azakenpaullone

Inhibits glycogen synthase kinase 3β (GSK3β)

1-Azakenpaullone

Inhibits glycogen synthase kinase 3β (GSK3β)

1-Azakenpaullone
5 mg
541 USD
Catalog # 74252

Inhibits glycogen synthase kinase 3β (GSK3β)

Overview

1-Azakenpaullone is a potent and highly selective inhibitor of glycogen synthase kinase 3β (IC₅₀ = 18 nM) and is highly preferential to GSK3β versus other cyclin-dependent kinases (CDKs) including CDK/cyclin B and CDK5/p25 (IC₅₀ = 2 µM and 4.2 µM, respectively; Kunick et al.).


MAINTENANCE AND SELF-RENEWAL
· In combination with ID-8 (Catalog #72502) and FK506 (Catalog #74152), supports human pluripotent stem cells in long-term propagation, maintaining pluripotency, and capacity to differentiate (Yasuda et al.).
Alternative Names
Not applicable
Cell Type
Pluripotent Stem Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Maintenance
Area of Interest
Stem Cell Biology
CAS Number
676596-65-9
Chemical Formula
C₁₅H₁₀BrN₃O
Molecular Weight
328.2 g/mol
Purity
≥ 98%
Target
GSK3β

Scientific Resources

Product Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Product Name
1-Azakenpaullone
Catalog #
74252
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
1-Azakenpaullone
Catalog #
74252
Lot #
All
Language
English

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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