LDN193189

BMP pathway inhibitor; Inhibits ALK1, ALK2, ALK3, and ALK6
Catalog #
72146_C
BMP pathway inhibitor; Inhibits ALK1, ALK2, ALK3, and ALK6
From: 202 USD

Overview

LDN193189 is a potent inhibitor of the bone morphogenetic (BMP) pathway, inhibiting ALK1, ALK2, ALK3, and ALK6 (IC50 = 0.8, 0.8, 5.3, and 16.7 nM respectively; Sanvitale et al.). It is a derivative of Dorsomorphin (Catalog #72102) that is typically used at approximately 100-fold lower concentrations (Sanvitale et al.; Vogt et al.). This product is supplied as the dihydrochloride salt of the molecule and it is the most soluble version of LDN193189.

DIFFERENTIATION
· Promotes differentiation of neural progenitor cells from human pluripotent stem cells (Chambers et al.; Kriks et al.).
· Promotes differentiation of neural crest cells from human pluripotent stem cells (Kreitzer et al.).
· Promotes differentiation of anterior foregut endoderm from human and mouse pluripotent stem cell-derived definitive endoderm (Kearns et al.).
· Promotes differentiation of sensory epithelial cells of the inner ear from mouse embryonic stem cells (Koehler et al.).

CANCER RESEARCH
· Inhibits prostate and breast cancer tumor growth (Balboni et al.; Lee et al.).
· Prevents ovarian cancer cell proliferation (Tsai et al.).
Alternative Names
DM-3189
Cell Type
Adipocytes, Cancer Cells and Cell Lines, Mammary Cells, Neural Cells, PSC-Derived, Pluripotent Stem Cells, Prostate Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Differentiation, Maintenance
Area of Interest
Neuroscience, Stem Cell Biology
CAS Number
1435934-00-1
Chemical Formula
C₂₅H₂₂N₆ · 2HCl
Molecular Weight
479.4 g/mol
Purity
> 98%
Pathway
BMP
Target
ALK1, ALK2, ALK3, ALK6

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
LDN193189 (Dihydrochloride)
Catalog #
72147, 72149
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
LDN193189 (Dihydrochloride)
Catalog #
72147, 72149
Lot #
All
Language
English

Educational Materials (5)

Brochure
Cytokines, Chemokines and Growth Factors
Brochure
Small Molecules for Stem Cell Research
Brochure
Small Molecules for Cancer Research
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Cancer Research

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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