Human Pluripotent Stem Cell Research

Induced pluripotent stem (iPS) cells are a type of pluripotent stem cell (PSC) that can be obtained by reprogramming somatic cells through artificial expression of key transcription factors under specific culture conditions.1-2 See More Variables that affect reprogramming include the delivery method, culture conditions and starting cell type. The choice of starting cell type is influenced by factors such as availability of donor tissue, invasiveness of sample collection procedures, genomic integrity, epigenetic memory and reprogramming efficiency. For efficient reprogramming, use our non-viral and non-integrating vector system, TeSR-based media, and small molecules. For blood-derived cells, we offer integrated kits to enrich, isolate, expand and reprogram erythroid progenitor or CD34+ progenitor cells. For help with your hPSC workflow decision making, use our infographics to find the right reagents for you.

References

  1. Takahashi K, et al. Cell 131(5): 861–72, 2007
  2. Yu J, et al. Science 318(5858): 1917–20, 2007
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Cell Culture Media and Supplements (42)

Matrices and Substrates (42)

Small Molecules (429)

  • CHIR99021

    CHIR99021

    WNT pathway activator; Inhibits GSK3
  • PD0325901

    PD0325901

    MEK/ERK pathway inhibitor; Inhibits MEK
  • SB431542

    SB431542

    Activin/BMP/TGF-β pathway inhibitor; Inhibits ALK4, ALK5, and ALK7
  • Valproic Acid (Sodium Salt)

    Valproic Acid

    Epigenetic modifier; Inhibits histone deacetylase (HDAC)1

Tissue and Cell Culture Dissociation Reagents (41)

Cell Storage Media (43)

  • CryoStor® CS2

    CryoStor® CS2

    Animal component-free, defined cryopreservation medium with 2% DMSO
  • CryoStor® CS5

    CryoStor® CS5

    Animal component-free, defined cryopreservation medium with 5% DMSO
  • CryoStor® CS10|07930

    CryoStor® CS10

    Animal component-free, defined cryopreservation medium with 10% DMSO

Antibodies (42)

Cultureware and General Supplies (41)

Buffers and Solutions (41)