Human Recombinant IGF-II

Insulin-like growth factor 2

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Insulin-like growth factor 2
From: 82 USD

Overview

Insulin-like growth factor 2 (IGF-II) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-II binding to IGF-I receptor activates a signaling cascade via the MAPK and PI3K pathways. IGF-II affects growth, differentiation, and survival of cells in a variety of tissues during embryonic development. It stimulates proliferation and migration of primary lymphatic endothelial cells, and induces lymphangiogenesis (Guvakova).
Alternative Names:
Insulin-like growth factor type 2, Insulin-like growth factor II, Somatomedin A, T3M-11-derived growth factor
Cell Type:
Prostate Cells; Neurons; Hematopoietic Stem and Progenitor Cells; Neural Stem and Progenitor Cells; Neural Cells, PSC-Derived
Species:
Human
Area of Interest:
Stem Cell Biology; Epithelial Cell Biology; Neuroscience
Molecular Weight:
7.5 kDa
Purity:
≥ 95%

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(2)

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This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant IGF-II was tested by its ability to promote the proliferation of FDC-P1 cells. Cell proliferation was measured after 48 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 1.1 - 1.6 ng/mL.
(B) 1 μg of Human Recombinant IGF-II was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IGF-II has a predicted molecular mass of 7.5 kDa.

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