Human Recombinant FGF-7 (KGF)

Fibroblast growth factor 7

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Fibroblast growth factor 7
From: 202 USD

Overview

Fibroblast growth factor 7 (FGF-7) is a member of the FGF family, and acts exclusively through a subset of FGF receptor isoforms expressed predominantly by epithelial cells (Finch & Rubin). FGF-7 seems to act specifically on epithelial cells and stimulates proliferation, migration, and differentiation of these cells, and also participates in epithelial protection and repair both in vitro and in vivo (Finch & Rubin; Werner). In contrast, FGF-7 is produced solely by cells of mesenchymal origin, and functions as a paracrine mediator of mesenchymal-epithelial communication (Rubin et al.). FGF-7 has also been shown to supplement several wound-healing properties of bioengineered skin (Erdag et al.) and to induce autophagy in human keratinocytes (Belleudi et al.). Additionally, FGF-7 has a role in pluripotent stem cell differentiation to endodermal pancreatic-like insulin-producing cells and thymic epithelial cells (Inami et al.; Niu et al.).
Alternative Names:
Fibroblast growth factor-7, HBGF-7, Heparin-binding growth factor 7, Keratinocyte growth factor
Cell Type:
Endoderm, PSC-Derived; Hematopoietic Stem and Progenitor Cells; Keratinocytes; Mammary Cells; Mesenchymal Stem and Progenitor Cells; Neural Cells, PSC-Derived; Neural Stem and Progenitor Cells; Pluripotent Stem Cells; Prostate Cells
Species:
Human
Area of Interest:
Epithelial Cell Biology; Neuroscience; Stem Cell Biology
Molecular Weight:
19 kDa
Purity:
≥ 95%

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Educational Materials

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Data and Publications

Data

(A) The biological activity of Human Recombinant FGF-7 (KGF) was tested by its ability to promote the proliferation of 4MBr-5 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 2 ng/mL. (B) 2 μg of Human Recombinant FGF-7 (KGF) was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant FGF-7 (KGF) has a predicted molecular mass of 19 kDa.

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