hPSC-Derived Endoderm Cell Research

Differentiate human pluripotent stem cells (hPSCs) to cells of the endoderm lineage with our specialized cell culture media. See MoreUse our definitive endoderm (DE) differentiation kit to obtain functional DE cells that are capable of downstream differentiation to hepatic, intestinal, pancreatic and pulmonary cells. To directly differentiate to pancreatic cells, use our pancreatic progenitor kit to generate functional PDX1⁺/NKX6.1⁺ cells that can be matured into insulin-producing beta cells. Further characterize the downstream cells with our high-quality verified antibodies .

Learn More

Webinar (50:33) Understanding Pancreatic Development and Diabetes Using Patient-Specific iPS Cells
Webinar (36:59) Derivation of Metabolically Active Hepatocytes from Human Pluripotent Stem Cells
Webinar (50:32) Understanding Pancreatic Development and Diabetes Using Patient-Specific iPS Cells
Scientific Poster Highly Efficient and Reproducible Differentiation of hPSCs to PDX1+/NKX6.1+ Pancreatic Progenitors

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Products

Cell Culture Media and Supplements (4 1)

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DMEM/F-12 with 15 mM HEPES

Dulbecco's Modified Eagle's Medium/Nutrient Ham's Mixture F-12 (DMEM/F-12) with 15 mM HEPES buffer

Small Molecules (4 5)

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LDN193189

BMP pathway inhibitor; Inhibits ALK1, ALK2, ALK3, and ALK6
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IWR-1-endo

WNT pathway inhibitor; AXIN2 stabilizer
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(-)-Indolactam V

Protein kinase C (PKC) activator
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Cyclopamine

Hedgehog pathway inhibitor; Inhibits Smoothened (SMO)

Antibodies (4 5)

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Anti-Human CD117 (c-Kit) Antibody, Clone 104D2

Mouse monoclonal IgG1 antibody against human, cynomolgus, cow CD117 (c-Kit)
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Anti-Human SSEA-4 Antibody, Clone MC-813-70

Mouse monoclonal IgG3 antibody against human, mouse, rat SSEA-4
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Anti-Human TRA-1-60 Antibody, Clone TRA-1-60R

Mouse monoclonal IgM antibody against human, rhesus, rabbit TRA-1-60 (podocalyxin)
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Anti-Human TRA-2-49 Antibody, Clone TRA-2-49/6E

Mouse monoclonal IgG1 antibody against human, chimpanzee, gibbon TRA-2-49 (tissue non-specific alkaline phosphatase)

Buffers and Solutions (4 1)

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D-PBS (Without Ca++ and Mg++)

Dulbecco’s phosphate-buffered saline without calcium and magnesium

Cultureware and General Supplies (4 1)

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Axygen® Sealing Film for Quantitative Real-Time PCR (qPCR)

Non-sterile, ultra-clear, pressure-sensitive sealing film for quantitative real-time PCR (qPCR)

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