Mouse Recombinant MIP-1 beta (CCL4)

Macrophage inflammatory protein-1 beta

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Macrophage inflammatory protein-1 beta
From: 196 USD

Overview

Macrophage inflammatory protein-1 beta (MIP-1 beta), also known as CCL4, is a member of the CC family of chemokines and is most closely related to CCL3 (MIP-1 alpha). Cellular sources of MIP-1 beta include activated leukocytes (monocytes and T and B cells), brain endothelial cells, and smooth muscle cells (Lukacs et al.; Menten et al.). MIP-1 beta, MIP-1 alpha, and RANTES have been shown to be major HIV-suppressive factors, possibly through the interactions of these chemokines with the receptor CCR5 on CD4+ T cells, which is also a major receptor for HIV entry into CD4+ T cells (Cocchi et al.; Menten et al.). MIP-1 beta attracts a variety of immune cells to sites of microbial infection. In addition to its chemotactic functions, MIP-1 beta induces the release of proinflammatory cytokines, mast cell degranulation, and NK cell activation (Schall et al.). In mice, recruitment of regulatory T cells to B cells and antigen-presenting cells by MIP-1 beta plays a central role in the initiation of T cell and humoral responses, and the depletion of regulatory T cells or MIP-1 beta results in deregulated humoral responses and production of autoantibodies (Bystry et al.).
Alternative Names:
ACT-2, Immune activation protein 2, LAG-1, Lymphocyte activation gene 1 protein, MIP-1b, Protein H400, SCYA2, SCYA4, Small-inducible cytokine A4, T-cell activation protein 2
Cell Type:
B Cells; Dendritic Cells; Mesenchymal Stem and Progenitor Cells; Monocytes; NK Cells; T Cells; T Cells, CD4+; T Cells, CD8+; Other
Area of Interest:
Immunology; Stem Cell Biology
Molecular Weight:
7.8 kDa
Purity:
≥ 95%

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Data and Publications

Data

(A) The biological activity of Mouse Recombinant MIP-1 beta (CCL4) was tested by its ability to induce chemotaxis of THP-1 cells. Cell migration was measured after 45 min using a fluorometric assay method. Increase in migration over basal level was seen starting at 100 ng/mL. (B) 1 μg of Mouse Recombinant MIP-1 beta (CCL4) was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant MIP-1 beta (CCL4) has a predicted molecular mass of 7.8 kDa.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.