Mouse Recombinant MIP-1 alpha (CCL3)

Macrophage inflammatory protein-1 alpha
Catalog #
78089_C
Macrophage inflammatory protein-1 alpha
From: 185 USD

Overview

Macrophage inflammatory protein-1 alpha (MIP-1 alpha), also known as CCL3, is a member of the CC family of chemokines and is most closely related to CCL4 or MIP-1 beta. Mouse MIP-1 alpha signal through CCR1, CCR3, CCR5, and D6 receptors (Menten et al.). MIP-1 alpha exhibits a variety of proinflammatory activities in vitro, including leukocyte chemotaxis, cytokine production, and mast cell activation, and it inhibits the proliferation of hematopoietic stem cells in vitro and in vivo (Cook). MIP-1 alpha plays a critical role in macrophage recruitment into wounds and in tissue repair (DiPietro et al.). It has been demonstrated that blockade of the CCL3/MIP-1 alpha-CCR1 pathway blocks the recruitment of CCR1-expressing CD4+ T cells to the liver, showing a therapeutic potential for treating T cell-mediated liver diseases (Ajuebor et al.).
Subtype
Cytokines
Alternative Names
AI323804, G0S19-1, LD78α, MIP-1a, SCYA3
Cell Type
B Cells, Dendritic Cells, Mesenchymal Stem and Progenitor Cells, Monocytes, NK Cells, Other, T Cells, T Cells, CD4+, T Cells, CD8+
Species
Mouse
Area of Interest
Immunology, Stem Cell Biology
Molecular Weight
7.9 kDa
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Mouse Recombinant MIP-1 alpha (CCL3)
Catalog #
78089
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Mouse Recombinant MIP-1 alpha (CCL3)
Catalog #
78089
Lot #
All
Language
English

Educational Materials (3)

Brochure
Tools For Your Immunology Research
Brochure
Cytokines, Chemokines and Growth Factors
Wallchart
Human Immune Cytokines

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Mouse Recombinant MIP-1 alpha (CCL3) was tested by its ability to induce chemotaxis of THP-1 cells. Cell migration was measured after 1 hour using a fluorometric assay method. Increase in migration over basal level was seen starting at 10 ng/mL. (B) 1 μg of Mouse Recombinant MIP-1 alpha (CCL3) was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant MIP-1 alpha (CCL3) has a predicted molecular mass of 7.9 kDa.

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