JAK Inhibitor I

JAK/STAT pathway inhibitor; Inhibits JAK1, JAK2, and JAK3
Catalog #
74022_C
JAK/STAT pathway inhibitor; Inhibits JAK1, JAK2, and JAK3
From: 136 USD

Overview

Janus Associated Kinase (JAK) Inhibitor I is a pyridine-containing tetracycle that disrupts JAK activity by interacting with the ATP binding domain. This inhibitor inhibits mouse JAK3 with Ki = 5 nM, JAK family members TYK2 and JAK2 with IC50 = 1 nM, and mouse JAK1 with IC50 = 15 nM, while showing weaker inhibition of other kinases (Thompson et al.).


REPROGRAMMING

· Inhibits the generation of mouse induced pluripotent stem cells (Efe et al.; Kim et al.).


IMMUNOLOGY

· Inhibits anti-viral response associated with JAK/STAT pathway activation (Xu et al.).
Alternative Names
CMP 6; Janus-associated kinase inhibitor I; Pyridone 6
Cell Type
Pluripotent Stem Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Maintenance, Reprogramming
Area of Interest
Stem Cell Biology
CAS Number
457081-03-7
Chemical Formula
C₁₈H₁₆FN₃O
"
Molecular Weight
309.3 g/mol
Purity
≥ 98%
Pathway
JAK/STAT
Target
JAK1, JAK2, JAK3

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
JAK Inhibitor I
Catalog #
74022, 74024
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
JAK Inhibitor I
Catalog #
74022, 74024
Lot #
All
Language
English

Educational Materials(5)

Brochure
Cytokines, Chemokines and Growth Factors
Brochure
Small Molecules for Stem Cell Research
Brochure
Small Molecules for Cancer Research
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Cancer Research

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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