iCell® GABANeurons Kit, 01279

GABA neurons derived from human iPS cells, frozen

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iCell® GABANeurons Kit, 01279

GABA neurons derived from human iPS cells, frozen

4 x 106 cells
Catalog #R1011

Overview

Traditional neuroscience research tools consist largely of rodent primary cell cultures and animal models, which are labor-intensive, costly, and poorly reflective of native human biology. iCell® GABANeurons represent a relevant human in vitro system for modeling and interrogating complex neurological processes and diseases.

iCell® GABANeurons are induced pluripotent stem (iPS) cell-derived mixed populations of human cerebral cortical neurons that exhibit native electrical and biochemical activity. They overcome limitations of existing models by providing the following:

• > 95% pure population of primarily GABAergic (inhibitory) neurons
• Rapid formation of neural networks and functional synapses
• Expression of relevant neurological therapeutic targets and pathways
• Long-term viability and demonstrated reproducibility
• Reliable supply in cryopreserved format

There is a broad range of peer-reviewed publications and CDI application protocols and applications notes to support your research goals, including:

• Alzheimer’s disease research and drug discovery: Functional tau and β-amyloid toxicity pathways, long-term viability, and flexible product format enable high-throughput screening for novel drug candidates
• Autism disease research: Demonstrated prefrontal cortex ionotropic glutamate receptors, GABAA receptor, and synaptic functionality drive interrogation of neurological diseases, such as autism
• Infectious disease studies: Susceptibility to varicella zoster virus infection and ability to maintain viral latency and reactivation
• Therapeutic potency testing: High sensitivity, dose-response, and biological responses to Clostridium botulinum neurotoxin (BoNT) aid replacement of the gold-standard mouse bioassay for BoNT potency testing
• Neurotoxicity assessment: Compatibility with a wide range of high-content, high-throughput platforms enables assessment of pharmaceutical and environmental neurotoxicity
Components:
iCell® GABANeurons, 01279, 4 x 10^6 cells
iCell® Neural Base Medium 1, 100 mL
iCell® Neural Supplement A, 2 mL
Subtype:
Frozen
Cell Type:
Neural Cells, PSC-Derived
Species:
Human
Cell and Tissue Source:
Pluripotent Stem Cells
Brand:
iCell
Donor Status:
Normal

Scientific Resources

Educational Materials

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Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.