Human Recombinant IL-33

Interleukin 33

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Human Recombinant IL-33

Interleukin 33

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Interleukin 33

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Overview

Interleukin 33 (IL-33) is a pro-inflammatory cytokine from the IL-1 family. It binds to ST2 receptor and activates NF-κB and MAPK pathways. IL-33 is expressed by epithelial cells, smooth muscle cells, and fibroblasts in various tissues and organs, as well as resting basophils, mast cells, eosinophils, natural helper cells, group 2 innate lymphoid cells, dendritic cells, and activated macrophages (Schmitz et al.; Yasuda et al.). It contributes to allergic inflammation by stimulating production of the cytokines IL-4, IL-5, and IL-13, and stimulates host defense against microbial and viral infections (Liew; Yasuda et al.). In the central nervous system, IL-33 is produced by endothelial cells and astrocytes. It induces proliferation of microglia and mediates production of pro-inflammatory cytokines (Yasuoka et al.).

Cytokines

Monocytes, T Cells, Other Subsets

Human

Immunology

≥ 95%

Data Figures

(A) The biological activity of Human Recombinant IL-33 was tested by its ability to promote the proliferation of D10S cells in low serum medium containing no other cytokines. Cell proliferation was measured after 67 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.1 - 0.15 ng/mL.
(B) 1 μg of Human Recombinant IL-33 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-33 has a predicted molecular mass of 18.1 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

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Product Name

Catalog #

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Document Type

Product Information Sheet

Product Name

Human Recombinant IL-33

Catalog #

78043, 78043.1

Lot #

All

Language

English

Document Type

Safety Data Sheet

Product Name

Human Recombinant IL-33

Catalog #

78043, 78043.1

Lot #

All

Language

English

Resources and Publications

Related Products

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STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.

Human Recombinant IL-33

Interleukin 33

Human Recombinant IL-33

Interleukin 33

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Overview

Data Figures

Protocols and Documentation

Resources and Publications

Educational Materials (3)

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