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Human Recombinant IGF-I, ACF

Insulin-like growth factor 1, animal component-free

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From: 55 USD

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Insulin-like growth factor 1, animal component-free
From: 55 USD

Overview

Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang et al.). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk et al.). This product is animal component-free.
Alternative Names:
IBP1, IGF-IA, IGF-IB, IGF1A, Insulin-like growth factor 1, Mechano growth factor, MGF, Somatomedin C
Cell Type:
Neural Cells, PSC-Derived; Neural Stem and Progenitor Cells; Prostate Cells
Area of Interest:
Epithelial Cell Biology; Neuroscience; Stem Cell Biology
Molecular Weight:
7.7 kDa
Purity:
≥ 95%

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Educational Materials

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This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant IGF-I, ACF was tested by its ability to promote the proliferation of FDC-P1 cells. Cell proliferation was measured after 72 hours in culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is 0.856 ng/mL. (B) 1 μg of Human Recombinant IGF-I, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.