Human Recombinant IGF-I, ACF

Insulin-like growth factor 1, animal component-free
Catalog #
78142_C
Insulin-like growth factor 1, animal component-free
From: 69 USD

Overview

Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang et al.). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk et al.). This product is animal component-free.
Subtype
Cytokines, Growth Factors
Alternative Names
IBP1, IGF-IA, IGF-IB, IGF1A, Insulin-like growth factor 1, Mechano growth factor, MGF, Somatomedin C
Cell Type
Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Prostate Cells
Area of Interest
Epithelial Cell Biology, Neuroscience, Stem Cell Biology
Molecular Weight
7.7 kDa
Purity
≥ 95%

Related Products

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant IGF-I, ACF
Catalog #
78142, 78142.1, 78142.2
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant IGF-I, ACF
Catalog #
78142, 78142.1, 78142.2
Lot #
All
Language
English

Educational Materials(3)

Brochure
Cytokines, Chemokines and Growth Factors
Brochure
Small Molecules for Stem Cell Research
Brochure
BrainPhys™ Neuronal Medium for Improved Neuronal Function

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant IGF-I, ACF was tested by its ability to promote the proliferation of FDC-P1 cells. Cell proliferation was measured after 72 hours in culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is 0.856 ng/mL. (B) 1 μg of Human Recombinant IGF-I, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

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