Honokiol

Natural lignan

Honokiol

Natural lignan

From: 362 USD
Catalog #
(Select a product)
Natural lignan
Add to Wish List

Overview

Reduce production of inflammatory factors with honokiol, a natural lignan. Derived from the plant Magnolia grandiflora, honokiol possesses antineoplastic and neuroprotective properties (Woodbury et al.). Honokiol inhibits the phosphorylation of Akt, a protein kinase that plays a role in regulating the production of inflammatory molecules (Kim and Cho). It also demonstrates anti-inflammatory effects by inhibiting nuclear factor kappa B (NF-κB) activation along with the production of inflammatory factors, such as nitric oxide (NO), tumor necrosis factor-α (TNF-α), and RANTES/CCL5 in glial cells (Zhang et al.).

Honokiol has been used for:

CANCER RESEARCH
· Induces apoptosis in various (breast, blood, prostate, and intestinal) cancer cells (Huang et al.; Shigemura et al.; Ishitsuka et al.).
· Reduces inflammation and senescence-associated biomarkers in cigarette smoke-damaged skin cells in vitro (Costa et al.).
· Blocks in vitro angiogenesis and in vivo tumor growth (Bai et al.).
DISEASE MODELING
· Promotes neurite growth and enhances survivability in rat cortical neurons (Fukuyama et al.).
· Protects rat cerebellar granule neurons from glutamate- and N-methyl-D-aspartate (NMDA)-induced excitotoxic injury as well as H2O2-induced neurotoxicity (Lin et al.).
· Induces anti-cardiac hypertrophic effects in vitro and in mice by activating mitochondrial SIRT3 (Pillai et al.).
Cell Type
Cancer Cells and Cell Lines
Area of Interest
Cancer, Disease Modeling
CAS Number
35354-74-6
Chemical Formula
C18H18O2
Molecular Weight
266.3 g/mol
Purity
≥ 98%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Product Name
Honokiol
Catalog #
100-1172
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Honokiol
Catalog #
100-1172
Lot #
All
Language
English