GANT 58

Hedgehog pathway inhibitor; Inhibits GLI1
Catalog #
73982_C
Hedgehog pathway inhibitor; Inhibits GLI1
From: 143 USD

Overview

GANT 58 inhibits the Hedgehog signaling pathway downstream of Smoothened and Suppressor of Fused (SUFU) leading to GLI1 nuclear accumulation (Joo et al.; Stanton & Peng). GANT 58 demonstrates antiproliferative and antitumor activity in vivo (Beauchamp et al.; Joo et al.).


CANCER RESEARCH
· Reduces anchorage-independent growth in Ewing Sarcoma cells (Beauchamp et al.; Joo et al.).
· Inhibits prostate cancer tumor growth (Lauth et al.).
· Causes cell cycle arrest and apoptosis in acute leukemia T cells (Hou et al.).
Alternative Names
NSC 75503
Cell Type
Cancer Cells and Cell Lines, Prostate Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Cell Culture
Area of Interest
Cancer
CAS Number
64048-12-0
Chemical Formula
C₂₄H₁₆N₄S
"
Molecular Weight
392.5 g/mol
Purity
≥ 98%
Pathway
Hedgehog
Target
GLI

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
GANT 58
Catalog #
73984
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
GANT 58
Catalog #
73984
Lot #
All
Language
English

Educational Materials (3)

Brochure
Cytokines, Chemokines and Growth Factors
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Cancer Research

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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