Numerous genetic and acquired conditions can impact skeletal muscle performance. Historically, 2D in vitro models of skeletal muscle have been limited in their ability to recapitulate the complex organization and function of skeletal muscle tissue__in conjunction with bones, tendons, and nerves.
Using a 3D printing and tissue engineering approach, Dr. Gilbert’s group has developed methods to grow arrays of human skeletal muscle tissues in vitro. Her work indicates that developmental processes and diseases that impact the communication between motor neurons and muscle can be more accurately studied in this 3D model than with classic 2D co-cultures. In this live webinar, Dr. Gilbert will explain how her group has uncovered regulators of muscle hypertrophy by inducing exercise-like rounds of contractions in their 3D skeletal muscle models.
Penney Gilbert, PhD
Associate Professor, University of Toronto
Canada Research Chair, Endogenous Repair
Live Webinar: 3D Modeling of Skeletal Muscle for In Vitro Functional Assaying
Friday May 17, 2019 - 10 a.m. PST | 1 p.m. EST | 6 p.m. UTC
If you are unable to attend the live webinar, please register and a link will be sent to you with the recorded version.
- 3D printing and tissue engineering methods for growing arrays of human skeletal muscle tissue in vitro.
- Developing 3D neuromuscular disease models by combining muscle tissue with motor neurons derived from hPSCs.
- Induction of exercise-like contractions in skeletal muscle to study regulators of muscular hypertrophy.
Dr. Gilbert is an Associate Professor at the University of Toronto in the Institute of Biomaterials and Biomedical Engineering. She holds cross-appointments in the Department of Biochemistry and in the Donnelly Centre. She received her PhD from the University of Pennsylvania under the mentorship of Dr. Valerie Weaver and pursued postdoctoral studies with Dr. Helen Blau at Stanford University. Her team engineers and studies 3D models of human skeletal muscle and explores muscle stem cell mechanobiology. She is the recipient of an Ontario Early Researcher Award and holds a Tier II Canada Research Chair in Endogenous Repair.