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Advance Breast Cancer Research with Mammary Organoids
Generating physiologically relevant mammary organoids can be challenging when using complex, variable media formulations. The MammoCult™ Organoid Kit (Human) and MammoCult™ Organoid Kit (Mouse) are modular, serum- and BPE-free culture systems designed to support the robust growth of mammary organoids from human or mouse tissue.
Organoids cultured with MammoCult™ maintain key mammary epithelial markers, lineage characteristics typical of luminal and basal populations, as well as strong estrogen receptor (ER) and progesterone receptor (PR) expression—features important for modeling both normal mammary biology and breast cancer.
Complete the form to be notified when MammoCult™ organoid kits become available and explore the data below to see how MammoCult™ supports marker expression and generates organoids suitable for cancer research.
Why Use MammoCult™?
- Preserve morphology and phenotype of the parental tissue, including expression of key lineage markers such as estrogen receptor (ER)
- Culture breast cancer organoid lines that enable disease modeling of triple-negative breast cancer (TNBC) and luminal breast cancers
- Support diverse cell populations by enabling expansion of luminal, basal, and multilineage organoids
- Streamline complex workflows with a defined, modular system that balances flexibility with ease of use
- Generate reproducible results with a consistent, serum-free system that minimizes variability across experiments
Figure 1. Luminal Cell-Derived Mammary Organoids Exhibit Robust Expression of Key Luminal Lineage Markers
Pure luminal organoid cultures (passage 1) were generated from non-sorted primary human mammary epithelial cells seeded in MammoCult™ Luminal Organoid Medium (LOM). The majority of organoids exhibit strong expression of luminal lineage markers MUC1, K8, ER, PR, and PMCA2 (n = 6 - 12), confirming their representative phenotype. The presence of secretory lineage luminal cells is validated by KIT expression (n = 10) and, more rarely, by co-expression of K8 and K14 (n = 3). These results demonstrate that MammoCult™ LOM enables the generation of physiologically relevant luminal mammary organoids that faithfully express lineage-specific markers, providing a powerful model for studying luminal cell biology and function. Scale bars = 100 µm.
If you would like to be notified as soon as we have more information and/or when MammoCult™ Organoid Kit (Human) and MammoCult™ Organoid Kit (Mouse) are available to order, please fill out the form on this page.
