
Cell Quality Attributes of Human Pluripotent Stem Cells
Human embryonic stem (ES) and induced pluripotent stem (iPS) cells are valuable tools for studying human development and disease, as well as a source of differentiated cells for use in regenerative medicine and drug discovery. With the first clinical trials underway, the assurance of the quality of these cells over long-term maintenance is critical for their safe use in clinical applications.
There are five cell quality attributes that you need to pay attention to: (1) genomic integrity, (2) pluripotency, (3) gene and marker expression, (4) epigenetic landscape and (5) culture system and morphology.