Showing 1 - 1 of 1 results for "78036"
- ReferenceM. Cerezo et al. (OCT 2018) Nature medicine
Translational control of tumor immune escape via the eIF4F-STAT1-PD-L1 axis in melanoma.Preventing the immune escape of tumor cells by blocking inhibitory checkpoints, such as the interaction between programmed death ligand-1 (PD-L1) and programmed death-1 (PD-1) receptor, is a powerful anticancer approach. However, many patients do not respond to checkpoint blockade. Tumor PD-L1 expression is a potential efficacy biomarker, but the complex mechanisms underlying its regulation are not completely understood. Here, we show that the eukaryotic translation initiation complex, eIF4F, which binds the 5' cap of mRNAs, regulates the surface expression of interferon-$\gamma$-induced PD-L1 on cancer cells by regulating translation of the mRNA encoding the signal transducer and activator of transcription 1 (STAT1) transcription factor. eIF4F complex formation correlates with response to immunotherapy in human melanoma. Pharmacological inhibition of eIF4A, the RNA helicase component of eIF4F, elicits powerful antitumor immune-mediated effects via PD-L1 downregulation. Thus, eIF4A inhibitors, in development as anticancer drugs, may also act as cancer immunotherapies. View Publication
Catalog #: Product Name: 10971 ImmunoCult™ Human CD3/CD28 T Cell Activator 15023 RosetteSep™ Human CD8+ T Cell Enrichment Cocktail 15021 RosetteSep™ Human T Cell Enrichment Cocktail 78036 Human Recombinant IL-2 (CHO-expressed) 85415 SepMate™-15 (IVD) 85450 SepMate™-50 (IVD) 86415 SepMate™-15 (RUO) 86450 SepMate™-50 (RUO) 10981 ImmunoCult™-XF T Cell Expansion Medium Catalog #: 10971 Product Name: ImmunoCult™ Human CD3/CD28 T Cell Activator Catalog #: 15023 Product Name: RosetteSep™ Human CD8+ T Cell Enrichment Cocktail Catalog #: 15021 Product Name: RosetteSep™ Human T Cell Enrichment Cocktail Catalog #: 78036 Product Name: Human Recombinant IL-2 (CHO-expressed) Catalog #: 85415 Product Name: SepMate™-15 (IVD) Catalog #: 85450 Product Name: SepMate™-50 (IVD) Catalog #: 86415 Product Name: SepMate™-15 (RUO) Catalog #: 86450 Product Name: SepMate™-50 (RUO) Catalog #: 10981 Product Name: ImmunoCult™-XF T Cell Expansion Medium