Showing 1 - 1 of 1 results for "19159"
- ReferenceC. A. Egelston et al. (OCT 2018) Nature communications 9 1 4297
Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression.
Functional CD8+ T cells in human tumors play a clear role in clinical prognosis and response to immunotherapeutic interventions. PD-1 expression in T cells involved in chronic infections and tumors such as melanoma often correlates with a state of T-cell exhaustion. Here we interrogate CD8+ tumor-infiltrating lymphocytes (TILs) from human breast and melanoma tumors to explore their functional state. Despite expression of exhaustion hallmarks, such as PD-1 expression, human breast tumor CD8+ TILs retain robust capacity for production of effector cytokines and degranulation capacity. In contrast, melanoma CD8+ TILs display dramatic reduction of cytokine production and degranulation capacity. We show that CD8+ TILs from human breast tumors can potently kill cancer cells via bi-specific antibodies. Our data demonstrate that CD8+ TILs in human breast tumors retain polyfunctionality, despite PD-1 expression, and suggest that they may be harnessed for effective immunotherapies. View PublicationCatalog #: Product Name: 17853 EasySep™ Human CD8 Positive Selection Kit II 19159 EasySep™ Human Memory CD8+ T Cell Enrichment Kit Catalog #: 17853 Product Name: EasySep™ Human CD8 Positive Selection Kit II Catalog #: 19159 Product Name: EasySep™ Human Memory CD8+ T Cell Enrichment Kit