Showing 1 - 1 of 1 results for "07910"
- ReferenceElliott G et al. (DEC 2015) Nature Communications 6 1 6363
Intermediate DNA methylation is a conserved signature of genome regulation
The role of intermediate methylation states in DNA is unclear. Here, to comprehensively identify regions of intermediate methylation and their quantitative relationship with gene activity, we apply integrative and comparative epigenomics to 25 human primary cell and tissue samples. We report 18,452 intermediate methylation regions located near 36% of genes and enriched at enhancers, exons and DNase I hypersensitivity sites. Intermediate methylation regions average 57% methylation, are predominantly allele-independent and are conserved across individuals and between mouse and human, suggesting a conserved function. These regions have an intermediate level of active chromatin marks and their associated genes have intermediate transcriptional activity. Exonic intermediate methylation correlates with exon inclusion at a level between that of fully methylated and unmethylated exons, highlighting gene context-dependent functions. We conclude that intermediate DNA methylation is a conserved signature of gene regulation and exon usage. View PublicationCatalog #: Product Name: 05750 NeuroCult™ NS-A Basal Medium (Human) 05751 NeuroCult™ NS-A Proliferation Kit (Human) 07923 Dispase (1 U/mL) 07910 Trypsin-EDTA (0.05%) 19157 EasySep™ Human Memory CD4+ T Cell Enrichment Kit 21000 RoboSep™-S 85850 mTeSR™1 07900 DNase I Solution (1 mg/mL) 36254 DMEM/F-12 with 15 mM HEPES Catalog #: 05750 Product Name: NeuroCult™ NS-A Basal Medium (Human) Catalog #: 05751 Product Name: NeuroCult™ NS-A Proliferation Kit (Human) Catalog #: 07923 Product Name: Dispase (1 U/mL) Catalog #: 07910 Product Name: Trypsin-EDTA (0.05%) Catalog #: 19157 Product Name: EasySep™ Human Memory CD4+ T Cell Enrichment Kit Catalog #: 21000 Product Name: RoboSep™-S Catalog #: 85850 Product Name: mTeSR™1 Catalog #: 07900 Product Name: DNase I Solution (1 mg/mL) Catalog #: 36254 Product Name: DMEM/F-12 with 15 mM HEPES
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