The monoclonal mouse CD69 antibody reacts with CD69, a gp28/34 disulfide bonded homodimer with a molecular weight of 60 kDa under non-reducing conditions. CD69, also known as the Very Early Activation Antigen, EA-1, Leu23, Activation Inducer Molecule (AIM) and CLEC2C, is a type II transmembrane protein that is constitutively expressed by activated platelets. Use this monoclonal antibody in applications requiring detection of CD69 such as flow cytometry (FC).

Studies show that CD69 crosslinking activates various events that lead to platelet activation and aggregation, such as calcium influx, degranulation, and arachidonate metabolism by cyclooxygenase. Upon activation of various lymphocytes, CD69 expression is induced in T cells, thymocytes, B cells, NK cells, neutrophils, and eosinophils, highlighting its role in lymphocyte signal transduction and activation. The protein also plays a role in signal transduction of natural killer cells and platelets. Diseases associated with CD69 dysfunction include coccidiodomycosis and asthma.