ABT-263

B cell lymphoma 2 family inhibitor

ABT-263

B cell lymphoma 2 family inhibitor

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B cell lymphoma 2 family inhibitor
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Overview

Regulate cancer cell apoptosis with ABT-263, a chemotherapeutic agent and an inhibitor of B cell lymphoma 2 (Bcl-2), B cell lymphoma-extra large (Bcl-xL), and Bcl-2-like protein 2 (Bcl-W) (Ki = < 1 nM, < 0.5, and < 1 nM, respectively). Bcl-2 and Bcl-xL are anti-apoptotic proteins that regulate cell death by interacting with pro-apoptotic proteins, like Bcl-2-like protein 11 (BIM), to induce or inhibit apoptosis (Tse et al.). ABT-263 displaces Bcl-xL from binding to BIM, allowing cells to undergo apoptosis (Lagares et al.).

ABT-263 has been used for:

IMMUNOLOGY
· Reduces expression of mitochondrial antiviral signaling protein (MAVS) in macrophages (Kim et al.).
· Induces apoptosis in influenza A virus-infected cells by activating the caspase 9-mediated mitochondrial apoptosis pathway (Kakkola et al.).
CANCER RESEARCH
· Inhibits tumor growth in small cell lung cancer xenograft models (Aguilar et al.).
· Acts as a selective senolytic in vitro by inducing apoptosis in senescent tumor cells after induction into senescence by chemotherapy or radiation (Saleh et al.).
· Promotes apoptosis in senescent murine Lewis lung carcinoma (LLC) cells (Saleh et al.).
· Induces G1/G0-phase arrest, apoptosis, and autophagy in human esophageal cancer cells (EC109, HKESC-2, and CaES-17) in vitro (Lin et al.).
Cell Type
B Cells
Area of Interest
Cancer, Immunology
CAS Number
923564-51-6
Chemical Formula
C47H55ClF3N5O6S3
Molecular Weight
974.6 g/mol
Purity
≥ 98%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Product Name
ABT-263
Catalog #
100-1173
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
ABT-263
Catalog #
100-1173
Lot #
All
Language
English

Resources and Publications