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product
ProstaCult™ Medium (Mouse) for mouse prostate epithelial cell culture
background
the prostate gland
The mouse prostate gland is a highly branched tubular organ composed of four distinct lobes: the anterior lobe (also known as the coagulating gland), the dorsal and lateral lobes (collectively referred to as the dorsolateral lobe), and the ventral lobe.1 Each lobe is composed of three functionally and morphologically distinct cell types. The most predominant cells are the secretory luminal cells, which are responsible for secretion of prostatic proteins. This cell type is androgen-dependent and expresses the luminal-specific markers Cytokeratin (CK) 8 and 18. The second major epithelial cell type is the basal cell, located between the luminal cells and the underlying basement membrane. The basal cell population expresses CK5 and CK14. It is speculated that the basal cell population contains a subset of cells with stem cell-like properties. Finally, the third prostatic epithelial cell type is the neuroendocrine cell, a minor population occupying the area closest to the basement membrane.1,2 Neuroendocrine cells secrete the neuroendocrine peptides required to support the viability and growth of luminal epithelial cells.1
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