Description
Ethan Shevach and Todd Davidson
Regulatory T cells are vital for keeping the immune system in check, helping to avoid immune-mediated pathology and unrestricted expansion of effector T cell populations. Accordingly, regulatory T cells have been the focus of extensive research over the past few years, and this has revealed diverse roles for those cells in numerous diseases, including autoimmunity, allergy, microbial infection and cancer. We now have a good understanding of how they arise, how they are maintained, how they exert their suppressive effects and how they might be harnessed for therapeutic intervention. This poster provides an updated overview of the development, phenotype and functions of regulatory T cells, in particular those subsets that express the transcription factor forkhead box P3 (FOXP3). The poster is freely available thanks to support from STEMCELL Technologies.
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