Pamela Wearsch and Peter Cresswell
The process by which antigen-presenting cells digest proteins from inside or outside the cell and display the resulting antigenic peptide fragments on cell surface MHC molecules for recognition by T cells is central to the body's ability to detect signs of infection or abnormal cell growth. As such, understanding the processes and mechanisms of antigen processing and presentation provides us with crucial insights necessary for the design of vaccines and therapeutic strategies to bolster T-cell responses.This poster provides an updated overview of the intracellular pathways and mechanisms by which antigens are captured, processed and loaded onto MHC class I, class II and CD1d molecules for presentation to T cells.
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