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| Cancer Research and Oncology |
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| Cancer Stem Cells: Review Articles |
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Alison MR, et al. Cancer stem cells: problems for therapy? J Pathol 223(2):148-162, 2011 |
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Alison MR, et al. Finding cancer stem cells: are aldehyde dehydrogenases fit for purpose? J Pathol 222(4):335-44, 2010 |
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Ma I & Allan AL. The Role of Human Aldehyde Dehydrogenase in Normal and Cancer Stem Cells. Stem Cell Rev & Rep Nov 2010 [Epub] |
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| Brain Cancer Cells |
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Bar EE, et al. Cyclopamine-Mediated Hedgehog Pathway Inhibition Depletes Stem-Like Cancer Cells in Glioblastoma. Stem Cells 25:2524–2533, 2007 |
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Rasper M, et al. Aldehyde dehydrogenase 1 positive glioblastoma cells show brain tumor stem cell capacity.
Neuro Oncol 12(10):1024-33, 2010 |
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Sun et al. DNER, an epigenetically modulated gene regulates glioblastoma-derived neurosphere cell differentiation. Stem Cells 27(7):1473-1486, 2009 |
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Huang Z, et al. Cancer stem cells in glioblastoma—molecular signaling and therapeutic targeting. Protein and Cell 1(7):638-655, 2010 |
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| Head and Neck Cancer Cells |
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Sun S & Wang Z. ALDHhigh adenoid cystic carcinoma cells display cancer stem cell properties and are responsible for mediating metastasis. Biochem Biophys Res Commun 396(4):843-8, 2010 |
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Ishizawa K, et al. Tumor-Initiating Cells Are Rare in Many Human Tumors. Cell Stem Cell. 7(3):279-282, 2010. |
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Clay MR, et al. Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase. Head Neck. 32(9):1195-201, 2010 |
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Boccia S., et al. Aldehyde Dehydrogenase 2 and Head and Neck Cancer: A Meta-analysis Implementing a Mendelian Randomization Approach. Cancer Epidemiol Biomarkers Prev 18:248, 2009 |
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| Thyroid Cancer Cells |
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Todaro M, et al. Tumorigenic and Metastatic Activity of Human Thyroid Cancer Stem Cells. Cancer Res 70(21):8874-85, 2010 |
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| Lung Cancer Cells |
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Jiang F, et al. Aldehyde Dehydrogenase 1 Is a Tumor Stem Cell-Associated Marker in Lung Cancer. Mol Cancer Res 7(3):330-8, 2009 |
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Moreb JS, et al. Heterogeneity of Aldehyde Dehydrogenase Expression in Lung Cancer Cell Lines Is Revealed by Aldefluor Flow Cytometry-Based Assay. Cytometry B Clin Cytom 72(4):281-9, 2007 |
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Sullivan JP, et al. Aldehyde Dehydrogenase Activity Selects for Lung Adenocarcinoma Stem Cells Dependent on Notch Signaling. Cancer Res 70(23):9937-48, 2010 |
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| Breast Cancer Cells |
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Ginestier C, et al. Retinoid signaling regulates breast cancer stem cell differentiation. Cell Cycle 8(20): 3297-302, 2009 |
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Ibarra I, et al. A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells. Genes Dev 21:3238-43, 2007 |
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Kakarala M, et al. Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast Cancer Res Treat 122(3):777-85, 2010 |
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Kurebayashi J, et al. Preferential antitumor effect of the Src inhibitor dasatinib associated with a decreased proportion of aldehyde dehydrogenase 1-positive cells in breast cancer cells of the basal B subtype. BMC Cancer 10(1):568, 2010 |
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Liu S, et al. BRCA1 regulates human mammary stem/progenitor cell fate. PNAS 105(5):1680-85, 2008 |
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Liu S, et al. Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks.
Cancer Res 71:614-624, 2011 |
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Xiao Y, et al. The lymphovascular embolus of inflammatory breast cancer exhibits a Notch 3 addiction. Oncogene 30:287-300, 2011 |
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Zhou L, et al. The prognostic role of cancer stem cells in breast cancer: a meta-analysis of published literatures. Breast Cancer Res Treat 122(3):795-801, 2010 |
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Zielske SP, et al. Loss of tumor-initiating cell activity in cyclophosphamide-treated breast xenografts. Transl
Oncol 3(3):149-52, 2010 |
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| Liver Cancer Cells |
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lMa, S., Chan, K. W., Lee, T. K., Tang K. H., Wo, J. Y., Zheng, B. J. & Guan, X. Y. Aldehyde Dehydrogenase Discriminates the CD133 Liver Cancer Stem Cell Populations. Mol. Cancer Res 6(7):1146-53, 2008 |
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| Pancreatic Cancer Cells |
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Feldmann G, et al. Blockade of Hedgehog Signaling Inhibits Pancreatic Cancer Invasion and Metastases: A New Paradigm for Combination Therapy in Solid Cancers. Cancer Res 67(5):2187-96, 2007 |
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Feldmann G, et al. An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer. Mol Cancer Ther 7(9):2725- 35, 2008 |
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Jimeno A, et al. A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development. Mol Cancer Ther 8(2):310–4, 2009 |
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Rasheed Z, et al. Isolation of stem cells from human pancreatic cancer xenografts. J Vis Exp 43(pii):2169, 2010 |
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| Kidney Cancer Cells |
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Krishnamurthy S, et al. Endothelial Cell-Initiated Signaling Promotes the Survival and Self-Renewal of Cancer Stem Cells. Cancer Res 70(23):1-10, 2010 |
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| Colon Cancer Cells |
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Carpentino JE, et al. Aldehyde Dehydrogenase-Expressing Colon Stem Cells Contribute to Tumorigenesis in the Transition from Colitis to Cancer. Cancer Res 69(20):8208-15, 2009 |
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Dalerba P, et al. Phenotypic characterization of human colorectal cancer stem cells. PNAS 104(24):10158-63, 2007 |
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Dylla SJ, et al. Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy. PLoS ONE 3(6):e2428, 2008 |
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Todaro M, et al. Colon cancer stem cells: promise of targeted therapy. Gastroenterology 138(6):2151-62, 2010 |
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| Hematopoietic Cancer Cells |
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Brennan SK, et al. Telomerase Inhibition Targets Clonogenic Multiple Myeloma Cells through Telomere Length-Dependent and Independent Mechanisms. PLoS ONE. 5(9) pii: e12487, 2010 |
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Cheung AMS, et al. Aldehyde dehydrogenase activity in leukemic blasts defines a subgroup of acute myeloid leukemia with adverse prognosis and superior NOD/SCID engrafting potential. Leukemia 21:1423-30, 2007 |
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Christ O, et al. Transplantation of Immunodeficient Mice with Chronic Myeloid Leukemia (CML) Cells from Chronic
Phase Patients Reveals a Hierarchy of CD34+ Aldehyde Dehydrogenase–Positive Cells with Short– and Long–Term Repopulating Activity and Transient Responsiveness to Imatinib Mesylate In Vivo. Blood, ASH Annual Meeting Abstracts 104(11):2960, 2004 |
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Foster SJ, et al. Specificity of the Flow Cytometric Aldehyde Dehydrogenase (ALDH) Assay in Hematopoietic Progenitor Cells and Tumor Cell Lines. Blood, ASH Annual Meeting Abstracts 102(11):3580, 2003 |
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Jones RJ, et al. Clonotypic B Cells Circulate in Hodgkins Lymphoma (HL). Blood, ASH Annual Meeting Abstracts 108(11):470, 2006 |
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Matsui W, et al. Clonogenic Multiple Myeloma Progenitors, Stem Cell Properties, and Drug Resistance. Cancer Res 68(1):190-7, 2008 |
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Nakamura S, et al. The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia. Carcinogenesis 31(11):2012-21, 2010 |
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Pearce DJ, et al. Characterization of Cells with a High Aldehyde Dehydrogenase Activity from Cord Blood and Acute Myeloid Leukemia Samples. Stem Cells 23:752-60, 2005 |
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Ran D, et al. Aldehyde dehydrogenase activity among primary leukemia cells is associated with stem cell features and correlates with adverse clinical outcome. Exp Hematol 37(12):1423-34, 2009 |
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Riccioni R, et al. M4 and M5 acute myeloid leukaemias display a high sensitivity to Bortezomib-mediated apoptosis.
Br J Haematol 139(2):194-205, 2007 |
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Taubert I, et al. Characterization of hematopoietic stem cell subsets from patients with multiple myeloma after mobilization with plerixafor. Cytotherapy 13(4):459-466, 2011 |
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| Prostate Cancer Cells |
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van den Hoogen C, et al. High Aldehyde Dehydrogenase Activity Identifies Tumor-Initiating and Metastasis-Initiating Cells in Human Prostate Cancer. Cancer Res 70(12):5163-73, 2010 |
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| Ovarian Cancer Cells |
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Deng S, et al. Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers. PLoS ONE 5(4): e10277, 2010 |
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Kryczek I, et al. Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells. Int J Cancer Feb 2011 [Epub] |
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| Bladder Cancer Cells |
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Su Y, et al. Aldehyde dehydrogenase 1 A1-positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancer. Cancer Epidemiol Biomarkers Prev 2:327-37, 2010 |
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