StemSpan® CC110

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Cytokine Cocktail for Expansion of Human Hematopoietic Cells

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  • Vial label for StemSpan® CC110 Cytokine Cocktail (100X) 1 mL
Vial label for StemSpan® CC110 Cytokine Cocktail (100X) 1 mL
StemSpan® CC110 contains a combination of recombinant human cytokines formulated to support the proliferation of human hematopoietic progenitors. It should be used in combination with StemSpan® SFEM or StemSpan® H3000 serum-free expansion media.
 
Supplied as 100X concentrate.
Product Name Description Catalog # Size Price Quantity
StemSpan® CC110 Cytokine cocktail for expansion of human hematopoietic cells 02697 1 mL 579.00 USD      
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Recommended for:
• Culture and expansion of human hematopoietic cells including CD34+ cells, stem cells and progenitor cells
• Contains early-acting cytokines and is primarily meant for use in short-term cultures to activate stem cell and immature progenitor cell cycling, without necessarily promoting the proliferation and differentiation of later progenitors
• Recommended if stem cell cycling is desired (i.e. for lentiviral and retroviral gene transfer)
Accessory Products:
• StemSpan® SFEM (Catalog #09600/09650)
• StemSpan® H3000 (Catalog #09800/09850)
Intended Use Statement: For Research Use Only. Not for Therapeutic or Diagnostic Use.
Contains:
• rh Flt-3 Ligand
• rh Stem Cell Factor
• rh Thrombopoietin
Product Type: Cytokines
Area of Interest: Cord blood banking, Hematopoietic stem cell research, Transplantation
Cell Type: Hematopoietic stem & progenitor cells
Popular Product Line: StemSpan
Research Area: Hematopoietic stem cell research

Procedures and instruction manuals:

Educational resources:

MSDS:

This product has been used in:

  1. "Leong et al. Mutant nucleophosmin deregulates cell death and myeloid differentiation through excessive caspase-6 and -8 inhibition.

Background References:

  1. Katrien Vanheusden et al. In vitro expanded cells contributing to rapid severe combined immunodeficient repopulation activity are CD34+38-33+90+45RA-.Stem Cells 25 (1) 107-114 (January 2007)
  2. Evgenios Goussetis et al. Intracoronary infusion of CD133+ and CD133-CD34+ selected autologous bone marrow progenitor cells in patients with chronic ischemic cardiomyopathy: cell isolation, adherence to the infarcted area, and body distribution.Stem Cells 24 (10) 2279-2283 (October 2006)
  3. E Conneally et al. Efficient retroviral-mediated gene transfer to human cord blood stem cells with in vivo repopulating potential.Blood 91 (9) 3487-3493 (May 1, 1998)
  4. C L Miller et al. Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability.Proc Natl Acad Sci U S A 94 (25) 13648-13653 (December 9, 1997)
  5. M E Lemieux et al. Differential ability of flt3-ligand, interleukin-11, and Steel factor to support the generation of B cell progenitors and myeloid cells from primitive murine fetal liver cells.Exp Hematol 25 (9) 951-957 (August 1997)
  6. M Bhatia et al. Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture.J Exp Med 186 (4) 619-624 (August 18, 1997)
  7. A Blair et al. Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo.Blood 89 (9) 3104-3112 (May 1, 1997)
  8. V I Rebel et al. Amplification of Sca-1+ Lin- WGA+ cells in serum-free cultures containing steel factor, interleukin-6, and erythropoietin with maintenance of cells with long-term in vivo reconstituting potential.Blood 83 (1) 128-136 (January 1, 1994)
  9. P M Lansdorp et al. Long-term erythropoiesis from constant numbers of CD34+ cells in serum-free cultures initiated with highly purified progenitor cells from human bone marrow.J Exp Med 175 (6) 1501-1509 (June 1, 1992)

Product Name

Description

Catalog #
StemSpan® SFEM Serum-Free Medium for Expansion of Hematopoietic Cells 09600
StemSpan® H3000 Xeno-Free and Serum-Free Medium for Expansion and Culture of Hematopoietic Cells 09800
StemSpan® CC100 Cytokine Cocktail for Expansion of Human Hematopoietic Cells 02690
StemSpan® CC220 Cytokine Cocktail for Expansion of Human Megakaryocyte Progenitors 02696

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