Human bronchial epithelial cells cultured at the air-liquid interface with PneumaCult™-ALI undergo extensive mucociliary differentiation to form a pseudostratified epithelium that closely resembles the human airway. Key features include the presence of highly motile cilia, production and secretion of mucus, and the development of stable transepithelial electrical resistance. Human bronchial epithelial cells cultured in PneumaCult™-ALI are a robust tool for studying development and disease states of the airway epithelium. Other applications include toxicity testing and preclinical drug development, including inhaled drug formulations.
