Vial label for rm Leukemia Inhibitory Factor 10 µg
Mouse Leukemia Inhibitory Factor (LIF) is a lymphoid factor which promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. LIF has a number of other activities including cholinergic neuron differentiation, control of stem cell pluripotency, bone and fat metabolism, mitogenesis of certain factor-dependent cell lines and promotion of megakaryocyte production in vivo. Mouse LIF is a 20 kDa protein containing 181 amino acid residues. The non-glycosylated, E. coli-expressed, recombinant LIF is indistinguishable from native LIF in its biological activity in vitro.
LIF is manufactured by Chemicon International Inc. and protected under US patents nos. 5,187,077, 5,427, 925, 5,443,825, 5,750,654 and 6,264,548; European patent no. 0285 448 and related foreign patents. It is not available for resale