GRO alpha/CXCL1 Human, Recombinant

GROα is a member of the a (CXC) family of chemokines. It is produced by monocytes, neutrophils, mast cells, epithelial cells, endothelial cells, keratinocytes and tumor cells. GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF. GROα is a chemoattractant for neutrophils, lymphocytes, monocytes, and epidermal melanocytes. In addition, GROα induces activation of neutrophils and basophils, has angiogenic effects, inhibits erythrocyte invasion and decreases the expression of interstitial collagen. GROα binds to IL-8R-A, IL-8R-B and DARC. Human GROα cDNA encodes a 107 amino acid residue precursor protein containing 34 N-terminal amino acid residues that are cleaved to generate the mature protein. The recombinant mature human GROα contains 73 amino acid residues and has an apparent molecular mass of 7.9 kDa.